Blood indices and circulating tumor cells for predicting metastasis of hepatocellular carcinoma after liver transplantation

Abstract Objectives Liver transplantation (LT) can benefit the long-term survival of hepatocellular carcinoma (HCC) patients. We hypothesized that circulating tumor cell (CTC) levels and subtypes are intimately associated with metastasis status HCC This study was designed to test compositive hematological indices including CTC provide a prediction post-LT metastasis. Methods Between 2017 2018, 37 patients within Hangzhou criteria receiving LT were included for analysis. The 24-month follow-up mainly conducted by outpatient telephone. Blood samples collected, examined. outcomes such as PFS, recurrence, metastasis, location recurrence/metastasis, number metastases recorded. Results analysis showed microvascular invasion (MVI) classification at baseline is Next, α-fetoprotein (AFP) level another useful indicator postoperative especially third or fourth month; protein induced vitamin K absence antagonist-II (PIVKA-II) three months after significantly higher those who had later mesenchymal 45th day increased in group. Using two-ends Logistic regression, calculated value MP (metastasis predictor, above factors). Had an AUC 0.858 ROC curve, cutoff 0.328. Conclusions In conclusion, invasion, AFP month, PIVKA-II 45 regression based on variables, two-year be predicted satisfactory sensitivity accuracy.